Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen alone or in combination with acetaminophen can effectively manage pain in adults and adolescents age 12 or older after having a tooth removed or when experiencing a toothache when dental care is not immediately available, according to a clinical practice guideline developed by the 福利姬视频 (ADA), the University of Pittsburgh School of Dental Medicine and the Center for Integrative Global Oral Health at the University of Pennsylvania School of Dental Medicine.
The toothache living guideline below will continue to update as new evidence becomes available. (Last updated May 2025.)
For additional recommendations: